Viral regulation of cell death

Matthew Reeves


CD34; latency; cytomegalovirus; HCMV


Chan G, Nogalski MT, Bentz GL, Smith MS, Parmater A & Yurochko AD 2010 PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes. J Immunol 184 3213-3222

Dupont L & Reeves MB 2016 Cytomegalovirus latency and reactivation: recent insights into an age old problem. Rev Med Virol 26 75-89

Kew V, Wills M & Reeves M 2017 HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors. J Mol Biochem 6 13-25

Kuan WL, Poole E, Fletcher M, Karniely S, Tyers P, Wills M, Barker RA & Sinclair JH 2012 A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity. J Exp Med 209 1-10

Randow F, MacMicking JD & James LC 2013 Cellular self-defense: how cell-autonomous immunity protects against pathogens. Science 340 701-706

McCormick AL 2008 Control of apoptosis by human cytomegalovirus. Curr Top Microbiol Immunol 325 281-295

Reeves MB, Breidenstein A & Compton T 2012 Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells. Proc Natl Acad Sci U S A 109 588-593

Reeves MB, Davies AA, McSharry BP, Wilkinson GW & Sinclair JH 2007 Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science 316 1345-1348

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