GRP78 expression in canine mammary tumors: association with malignancy

Joana T de Oliveira; Cláudia Ribeiro; Fátima Gärtner

GRP78 expression in canine mammary tumors: association with malignancy

Joana T de Oliveira, Cláudia Ribeiro, Fátima Gärtner

Abstract

78-kDa glucose-regulated protein (GRP78) is over-expressed in human breast carcinomas. GRP78 expression was studied in 40 spontaneous canine mammary tumors and evaluated in relation to tumor histological type, mode of growth, grade, lymph node metastases and distant metastases. All tumors exhibited GRP78 immunostaining. In the normal canine mammary gland, GRP78 was also expressed although not in all cases. In carcinomas GRP78 was detected in the cytoplasm in more than 50% of tumor cells in the vast majority of cases (87.5%). There was a significant association between the absence of squamous differentiation (P = 0.02) and GRP78 over-expression, but no association with other clinico-pathological features. GRP78 was often co-expressed with galectin-3 in canine mammary tumors (CMT).

Keywords

GRP78; Mammary tumors; Canine; Microenvironment; Malignancy

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