RETRACTED ARTICLE: The biochemistry of male homosexuality
Abstract
Homosexuality is a common occurrence in humans and other species. It is a complex, universal phenomenon whose genetic and evolutionary basis is poorly understood. Despite great progress in the sciences, our understanding of the determinants of sexual orientation and, more specifically, of male homosexuality, is incomplete. In this paper, we have reviewed the biological causes of male homosexuality, which may provide clues for further research in this field, as provable biological or genetic differences between heterosexuals and homosexuals that weren't caused by their behaviour haven’t been found.
This article has been retracted due to plagiarism. An erratum will be published in Volume 3, Issue 1 (2014).
Keywords
References
Allen LS, Hines M, Shryne JE & Gorski RA 1989 Two sexually dimorphic cell groups in the human brain. J Neurosci 9 497-506
Allen LS & Gorski RA 1992 Sexual orientation and the size of the anterior commissure in the human brain. Proc Natl Acad Sci USA 89 7199-7202
Archer J & Mehdikhani M 2003 Variability among males in sexually selected traits. Review of General Psychology 7 219-236
Arnold AP 2004 Sex chromosomes and brain gender. Nat Rev Neurosci 5 701-708
Arnqvist G & Rowe L 2005 Sexual conflict. Princeton, NJ: Princeton University Press
Bailey JM & Pillard RC 1991 A genetic study of male sexual orientation. Arch Gen Psychiatry 48 1089-1096
Bailey JM, Pillard RC, Dawood K, Miller MB, Farrer LA, Trivedi S & Murphy RL 1999 A family history study of male sexual orientation using three independent samples. Behav Genet 29 79-86
Barahal HS 1940 Testosterone in psychotic male homosexuals. Psychiatric Quarterly 14 319-330
Beach FA 1979 Animal models for human sexuality. In R Porter & J Whelan (eds), Sex hormones, and behaviour (pp. 113-143). Amsterdam: Experta Medica
Birk L, Williams GH & Chasin M 1973 Serum testosterone levels in homosexual men. N Engl J Med 289 1236-1238
Blanchard R 1997 Birth order and sibling sex ratio in homosexual versus heterosexual males and females. Annu Rev Sex Res 8 27-67
Blanchard R 2001 Fraternal birth order and the maternal immune hypothesis of male homosexuality. Horm Behav 40 105-114
Blanchard R 2004 Quantitative and theoretical analyses of the relation between older brothers and homosexuality in men. J Theor Biol 230 173-187
Blanchard R 2007 Supplementary analyses regarding Langevin, Langevin, and Curnoe’s (2007) findings on fraternal birth order in homosexual men. Archiv Sex Behav 36 610-614
Blanchard R & Bogaert AF 1996 Homosexuality in men and number of older brothers. Am J Psychiatry 153 27-31
Blanchard R & Bogaert AF 2004 Proportion of homosexual men who owe their sexual orientation to fraternal birth order: An estimate based on two national probability samples. Am J Hum Biol 16 151-157
Blanchard R & Lippa RA 2007 Birth order, sibling sex ratio, handedness, and sexual orientation of male and female participants in a BBC Internet research project. Archiv Sex Behav 36 163-176
Blanchard R & Sheridan PM 1992 Sibship size, sibling sex ratio, birth order, and parental age in homosexual and nonhomosexual gender dysphorics. J Nerv Ment Dis 180 40-47
Blanchard R & Zucker KJ 1994 Reanalysis of Bell, Weinberg, and Hammersmith’s data on birth order, sibling sex ratio, and parental age in homosexual men. Am J Psychiatry 151 1375-1376
Blanchard R & Klassen P 1997 H-Yantigen and homosexuality in men. J Theor Biol 185 373-378
Blanchard R & Ellis L 2001 Birth weight, sexual orientation, and the sex of preceding siblings. J Biosoc Sci 33 451-467
Blanchard R, Cantor JM, Bogaert AF, Breedlove SM & Ellis L 2006 Interaction of fraternal birth order and handedness in the development of male homosexuality. Horm Behav 49 405-414
Blanchard R, Zucker KJ, Siegelman M, Dickey R & Klassen P 1998 The relation of birth order to sexual orientation in men and women. J Biosoc Sci 30 511-519
Blanchard R, Zucker KJ, Cavacas A, Allin S, Bradley SJ & Schachter DC 2002 Fraternal birth order and birth weight in probably prehomosexual feminine boys. Horm Behav 41 321-327.
Blanco P, Sargent CA, Boucher CA, Mitchell M & Affara NA 2000 Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain. Mamm Genome 11 906-914
Bobrow D & Baile MJ 2001 Is male homosexuality maintained via kin selection. Evol Hum Behav 22 361-368
Bocklandt S, Horvath S, Vilain E & Hamer DH 2006 Extreme skewing of X chromosome inactivation in mothers of homosexual men. Human Genet 118 691-694
Bogaert AF 2006 Biological versus nonbiological older brothers and men’s sexual orientation. Proc Natl Acad Sci 103 10771-10774
Bogaert AF, Blanchard R & Crosthwait LE 2007 Interaction of birth order, handedness, and sexual orientation in the Kinsey interview data. Behav Neurosci 121 845-853
Brodie HKH, Gartrell N & Doering C 1974 Plasma testosterone levels in heterosexual and homosexual men. Am J Psychiatry 131 82-83
Camperio-Ciani A, Corna F & Capiluppi C 2004 Evidence for maternally inherited factors favouring male homosexuality and promoting female fecundity. Proc Royal Soc B 271 2217-2221
Cantor JM, Blanchard R, Paterson AD & Bogaert AF 2002 How many gay men owe their sexual orientation to fraternal birth order? Archiv Sex Behav 31 63-71
Carlson NR 1977 Psychology of behavior. Boston: Allyn & Bacon
Cooper AJ 1978 Aetiology of homosexuality. In JA Loraine (ed), Understanding homosexuality (pp. 1-23). New York: Elsevier
Darke RA 1948 Heredity as an etiological factor in homosexuality. J Nerv & Ment Dis 107 251-268
Delozier CD & Engle E 1982 Sexual differentiation as a model for genetic and environmental interaction affecting physical and psychological development. In WR Gove & GR Carpenter (eds), The fundamental connection between nature and nurture (pp. 117-136), Toronto, Ontario: Lexington Books.
Diamond M 1993 Homosexuality and bisexuality in different populations. Archiv Sex Behav 22 291-310
Doerr P, Kockott G & Bogt HJ 1973 Plasma testosterone, estradiol and semen analysis in male homosexuals. Archiv Gen Psychiatry 29 829-833
Domer G, Docke F & Moustafa S 1968a Differential localization of a male and female hypothalamic mating center. J Reprod Ster 17 583-586
Dorner G, Docke F & Moustafa S 1968b Homosexuality in female rats following testosterone implantation in the anterior hypothalamus. J Reprod Ster 17 173-175
Dorner G, Geier T, Ahrens L, Krell L, Munx G, Sieler H, Kittner E & Muller H 1980 Prenatal stress and possible aetiogenetic factor homosexuality in human males. Endokrinologie 75 365-368
Dorner G, Schenk B, Schmiedel B & Ahrens L 1983 Stressful events in prenatal life of bi- and homosexual men. Experiment Clinic Endocrinol SI 83-87
Ehrhardt AA 1975 Prenatal hormonal exposure and psychosexual differentiation. In E Sachar (ed), Topics in psychoendocrinotogy (pp. 1307-1308). New York: Grune & Stratton
Ehrhardt AA, Epstein R & Money J 1968 Fetal androgens and female gender identity in the early treated andrenogenital syndrome. Johns Hopkins Med J 122 160-167
Ellis H 1915 Studies in the psychology of sex: Vol. 2. Sexual inversion (3rd ed). Philadelphia, PA: Davis
Ellis L 1996 The role of perinatal factors in determining sexual orientation. In RC Savin-Williams & KM Cohen (eds), The lives of lesbians, gays, and bisexuals: Children to adults (pp. 35-69). Fort Worth, TX: Harcourt Brace.
Ellis L & Ames MA 1987 Neurohormonal functioning and sexual orientation: A theory of homosexuality-heterosexuality. Psychol Bulletin 101 233-258
Ellis L & Blanchard R 2001 Birth order, sibling sex ratio, and maternal miscarriages in homosexual and heterosexual men and women. Person Individ Diff 30 543-552
Ellis L & Cole-Harding S 2001 The effects of prenatal stress, and of prenatal alcohol and nicotine exposure, on human sexual orientation. Physiol Behav 74 213-226
Fisher LK, Kogut MD, Moore RJ, Goebelsmann U, Weitzman JJ, Isaacs H Jr, Griffin JE & Wilson JD 1978 Clinical, endocrinological and enzymatic characterization of two patients with 5-a-reductase deficiency: Evidence that a single enzyme is responsible for the 5 alpha-reduction of cortisol and testosterone. J Clinic Endocrinol Metab 47 653-664
Forel A 1924 The sexual question. New York: Physicians and Surgeons Book Company.
Francis AM 2008 Family and Sexual Orientation: The Family-Demographic Correlates of Homosexuality in Men and Women. J Sex Res 45 371-377
Friedman RC, Dyrenfurth I, Linkie D, Tendler R & Fleiss JL 1976 Hormones and sexual orientation in males. Am J Psychiatry 134 57-72
Gentele H, Lagerholm B & Lodin A 1960 The chromosomal sex of male homosexuals. Acta Dermato- Venereologica 40 470-473
Gladue BA, Green R & Hellman RE 1984 Neuroendocrine response to estrogen and sexual orientation. Science 225 1496-1499
Glass J, DeVel HJ & Wright CA 1940 Sex hormone studies in male homosexuality. Endocrinol 26 590-594
Green R 2000 Birth order and ratio of brothers to sisters in transsexuals. Psycholog Med 30 789-795
Grumbach M 1979 Genetic mechanisms of sexual development. In HL Vallet & IH Porter (eds), Genetic mechanisms of sexual development (pp 33-71). New York: Academic Press
Hamer D 1999 Genetics and male sexual orientation. Science 285 803
Hamer D, Hu S, Magnuson V, Hu N & Pattatucci AM 1993a A linkage between DNA markers on the X chromosome and male sexual orientation. Science 261 321-327
Hammer D & Copeland P 1994 The science of desire: the search for the gay gene and biology of behavior. New York, US: Simon & Schuster
Henry GW 1941 Sex Variants: A Study of Homosexual Patterns. New York, US: Hoeber
Hare EH & Moran PA 1979 Parental age and birth order in homosexual patients: A replication of Slater’s study. Brit J Psychiatry 134 178-182
Hines M 2004 Brain gender. Oxford: Oxford University Press
Hirschfeld M 1920 Die Homosexualitat des Marines und des Weibes. [Homosexuality in men and women] Berlin: Marcus
Hu S, Pattatucci AM, Patterson C, Li L, Fulker DW, Cherny SS, Kruglyak L & Hamer DH 1995 Linkage between sexual orientation and chromosome Xq28 in males but not females. Nat Genet 11 248-256
Hull EM, Franz JR, Snyder AM & Nishita JK 1980 Perinatal progesterone and learning, social and reproductive behavior in rats. Physiol Behav 24 251-256
Hutchinson GE 1959 A speculative consideration of certain forms of sexual selection in man. Am Nat 93 81-91
Imperato-McGinley J, Guerrero L, Gauthier T & Peterson RE 1974 Steroid 5-a-reductase deficiency in man: An inherited form of male pseudohermaphroditism. Science 186 1213-1215
Imperto-McGinley J, Peterson RE, Goutier T & Sturla E 1979 Androgens and the evolution of male-gender identity among male psuedohermaphrodites with 5-a-reductase deficiency. N Engl J Med 300 1233-1239
Jamain S, Quach H, Betancur C, RÃ¥stam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, Bourgeron T & Paris Autism Research International Sibpair Study 2003 Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet 34 27-29
Jensch K 1941a Zur Genealogie der Homosexualitat [Regarding the genetics of homosexuality]. Archiv fur Psychiatrie und Nervenkrankheiten 112 527-540
Jensch K 1941b Weiterer Beitrag zur Genealogie der Homosexualitat [A further contribution regarding the genetics of homosexuality]. Archiv fur Psychiatrie und Nervenkrankheiten 112 679-696
Jobling MA, Lo IC, Turner DJ, Bowden GR, Lee AC, Xue Y, Carvalho-Silva D, Hurles ME, Adams SM, Chang YM, Kraaijenbrink T, Henke J, Guanti G, McKeown B, van Oorschot RA, Mitchell RJ, de Knijff P, Tyler-Smith C & Parkin EJ 2007 Structural variation on the short arm of the human Y chromosome: Recurrent multigene deletions encompassing. Amelogenin Y. Hum Mol Genet 16 307-316
Kallman FJ 1952 Comparative twin study on the genetic aspects of male homosexuality. J Nerv Ment Dis 115 283-298
King M, Green J, Osborn DP, Arkell J, Hetherton J & Pereira E 2005 Family size in white gay and heterosexual men. Archiv Sex Behav 34 117-122
Kirsch JAW & Weinrich JD 1991 Homosexuality, nature, and biology: is homosexuality natural? Does it matter? In Homosexuality: research implications for public policy (ed. J Gonsiorek & J Weinrich), pp 13-31. Newbury Park, CA, US: Sage Publications
Kolodny RC, Masters WH & Hendryx J 1971 Plasma testosterone and semen analysis in male homosexuals. N Engl J Med 21 1170-1174
Lalumiere ML, Blanchard R & Zucker KJ 2000 Sexual orientation and handedness in men and women: A meta-analysis. Psychol Bull 126 575-592
Lang T 1936 Beitrag zur Frage nach der genetischen Bedingtheit der Homosexualitat [A contribution regarding the question of the genetic determination of homosexuality]. Zeitschrift fur die gesamte Neurologie und Psychiatrie 155 702-713
Lang T 1937 Weiterer Beitrag zur Frage nach der genetischen Bedingtheit der Homosexualitaet [Further contribution to the question of the genetic determination of homosexuality]. Zeitschrift fuer die Gesamte Neurologie und Psychiatrie 157 557-574
Lang T 1940 Studies on the genetic determination of homosexuality. J Nerv Ment Dis 92 55-64
Lang T 1960 Die Homosexualita¨t als genetisches Problem [Homosexuality as a genetic problem]. Acta Geneticae Medicae et Gemellologiae 9 370-381
Laumann EO, Gagnon JH, Michael RT & Michaels S 1994 The social organization of sexuality: Sexual practices in the United States. Chicago, US: The University of Chicago Press
LeVay S 1991 A difference in Hypothalamic Structure Between Heterosexual and Homoswxual Men. Science 253 1034-1037
Lippa RA 2003 Handedness, sexual orientation, and gender-related personality traits in men and women. Archiv Sex Behav 32 103-114
Loraine JA, Ismail AA, Adamopoulos DA & Dove GA 1970 Endocrine function in male and female homosexuals. Brit Med J 4 406-409
MacIntyre F & Estep KW 1993 Sperm competition and the persistence of genes for male homosexuality. Biosystems 31 223-233
McKnight J 1997 Straight science? Homosexuality, evolution and adaptation. London, UK: Routledge
McKusick VA 1992 Mendelian Inheritance in Man. Baltimore, US: Johns Hopkins University Press
Meyer-Bahlburg H 1984 Psychoendocrine research on sexual orientation: Current status and future options. In GJ De Vries, JPC De Bruin, HMB Uylings & MA Corner, (eds), Progress in brain research (Vol. 61, pp 375-398). Amsterdam: Elsevier
Miller EM 2000 Homosexuality, birth order, and evolution: Toward an equilibrium reproductive economics of homosexuality. Archiv Sex Behav 29 1-34
Money J, Ehrhardt AA & Masica DN 1968 Fetal feminization induced by androgen insensitivity in the testicular feminization syndrome: Effects on marriage and maternalism. Johns Hopkins Med J 123 105-114
Money J 1969 Sexually dimorphic behavior, normal and abnormal. In N Kretchmer & DN Walcher (eds), Environmental influences on genetic expression (pp. 201-212). Washington DC, US: U.S. Government Printing Office
Muscarella F 2000 The evolution of homoerotic behavior in humans. J Homosex 40 51-77
Mustanski BS, Chivers ML & Bailey JM 2002 A critical review of recent biological research on human sexual orientation. Ann Rev Sex Res 13 89-140
Mustanski BS, DuPree MG, Nievergelt CM, Bocklandt S, Schork NJ & Hamer DH 2005 A genomewide scan of male sexual orientation. Hum Gen DOI: 10.1007/s00439-004-1241-4
Ott J 1991 Analysis of Human Genetic Linkage. Baltimore, US: Johns Hopkins Univ. Press
Pare CMB 1956 Homosexuality and chromosomal sex. J Psychosom Res 1 247-251
Phoenix CH, Goy RW, Gerall AA & Young WC 1959 Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behaviour in the female guinea pig. Endocrinol 65 369-382
Pillard RC, Rose RM & Sherwood M 1974 Plasma testosterone levels in homosexual men. Archiv Sex Behav 3 453-458
Pillard RC, Poumadere J & Carretta RA 1981 Is homosexuality familial? A review, some data, and a suggestion. Archiv Sex Behav 10 465-473
Pillard RC, Poumadere J & Carretta RA 1982 A family study of sexual orientation. Archiv Sex Behav 11 511-520
Pillard RC & Weinrich JD 1986 Evidence of familial nature of male homosexuality. Arch Gen Psychiatry 43 808-812
Rahman Q 2005 Fluctuating asymmetry, second to fourth finger length ratios and human sexual orientation. Psychoneuroendocrinol 30 382-391
Rahman Q & Wilson GD 2003 Born gay? The psychobiology of human sexual orientation. Person Individ Diff 34 1337-1382
Rice WR 1984 Sex-chromosomes and the evolution of sexual dimorphism. Evolution 38 735-742
Rice G, Anderson C, Risch N & Ebers G 1999 Male homosexuality: absence of linkage to microsatellite markers at Xq28. Science 284 665-667
Rice WR & Holland B 1997 The enemies within: intergenomic conflict, interlocus contest evolution (ICE) and the intraspecific Red Queen. Behav Ecol Sociobiol 41 1-10
Robertson I 1977 Sociology. New York, US: Worth
Robinson SJ & Manning JT 2000 The ratio of 2nd to 4th digit length and male homosexuality. Evol Hum Behav 21 333-345
Rubin RX, Reinisch JM & Haskett RF 1981 Postnatal gonadal steroid effects on human behavior. Science 211 1318-1324
Saba P, Salvadorini F, Galeone F & Luisi M 1973 Hormonal findings in male homosexuals. IRCS Med Sci Psychol Psychiatry 3 15
Saenger P, Goldman AS, Levine LS, Korthschutz S, Muecke C, Katsuma M, Doberre Y & New MI 1978 Prepubertal diagnosis of steroid 5-or-reductase deficiency. J Clin Endocrinol Metab 46 627-634
Savage MO, Preece MA, Jeffcoat SL, Ransley PG, Rumsby G, Mansfield MD & Williams DI 1980 Familial male pseudohermaphroditism due to deficiency of 5a-reductase. Clin Endocrinol 12 397-406
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S & Page DC 2003 The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423 825-837
Slater E 1962 Birth order and maternal age of homosexuals. Lancet 1 69-71
Swaab DF & Fliers E 1985 A sexually dimorphic nucleus in the human brain Science 228 1112-1115
Swaab DF & Hofman MA 1990 Brain Res 537 141-148
Tourney G & Hatfield LM 1973 Androgen metabolism in schizophrenics, homosexuals, and normal controls. Biol Psychiatry 6 23-36
Vasey PL & VanderLaan DP 2007 Birth order and male androphilia in Samoan fa’afafine. Proc Royal Soc B 274 1437-1442
Von Kraft-Ebbing R 1965 Psychopathia sexualis. New York, US: Stein & Day. (Original work published 1886).
Ward IL & Ward OB 1985 Sexual behaviour differentiation: Effects of prenatal manipulations in rats. In N Alder, D Pfaff & RW Goy (eds), Handbook of behavioral neurobiology: Reproduction (Vol. 7, pp. 77-98.) New York, US: Plenum
Ward OB 1992 Fetal drug exposure and sexual differentiation of males. In AA Gerall, H Moltz & IL Ward (eds), Handbook of behavioral neurobiology: Vol. II. Sexual differentiation (pp 181-219). New York, US: Plenum
Weinrich JD 1987 Sexual landscapes. New York, US: Scribner’s
Williams TJ, Pepitone ME, Christensen SE, Cooke BM, Huberman AD, Breedlove NJ, Breedlove TJ, Jordan CL & Breedlove SM 2000 Finger-length ratios and sexual orientation. Nature 404 455-456
Wilson EO 1975 Sociobiology: the new synthesis. Cambridge, MA, US: Harvard University Press
Witschi E & Mengert WF 1942 Endocrine studies on human hermaphrodites and their bearing on the interpretation of homosexuality. J Clin Endocrinol 2 279-286
Zucker KJ & Blanchard R 1994 Reanalysis of Bieber et al.’s 1962 data on sibling sex ratio and birth order in male homosexuals. J Nerv Ment Dis 182 528-530
Zucker KJ, Beaulieu N, Bradley SJ, Grimshaw GM & Wilcox A 2001 Handedness in boys with gender identity disorder. J Child Psychol Psychiatry 42 767-776
Zuger B 1989 Homosexuality in families of boys with early effeminate behavior: an epidemiological study. Arch Sex Behav 18 155-66
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