SOCS, inflammation, and metabolism

Kyoko Inagaki-Ohara, Akihiko Yoshimura


Obesity is characterized by the development of low-grade chronic inflammation, which is a contributing factor in defective energy metabolism. A hallmark of metabolic dysregulation, obesity is a life-style disease that contributes to diabetes, hypertension, and dyslipidemia. Further, recent studies warn that obesity can be a risk factor for certain cancers and exacerbates infectious diseases. This association is called the “metabolic domino”. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of cytokine and hormone signaling mediated by the JAK-STAT signaling pathway. SOCS proteins regulate cell-cell communication through JAK-STAT-dependent cytokines and signaling by Toll-like receptors (TLRs) and they may be influenced by dietary factors such as fatty acids and glucose. In this review, we focus on the role of the JAK-STAT-SOCS signaling cascade in metabolic disorder and obesity-related diseases.


SOCS; obesity; cancer; leptin; insulin


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