Molecular mechanism-based model to enhance outcomes of dietary intervention studies for disease prevention

Moul Dey

Abstract


Advances in “omics”-based fields have produced an explosion of new information, fueling high expectations for improved public and individualized health. Unfortunately, there exists a widening gap between basic biochemistry and “omics”-based population research, with both disciplines failing to translate their full potential impact to human health applications. A paucity of comprehensive study systems is one of the many roadblocks faced by translational research today. This commentary will highlight the current status of such research, particularly emphasizing the role of nutrigenomics.


Keywords


molecular nutrition; nutritional biochemisty; nutrigenomics

References


Frank AL 1996 Prevention into the 21st century. Mt Sinai J Med 63 236-240.

Ginsburg D 2011 Genetics and Genomics to the Clinic: A Long Road ahead. Cell 147 17-19.

Go VL, Butrum RR & Wong DA 2003 Diet, nutrition, and cancer prevention: the postgenomic era. J Nutr 133 3830S-3836S.

Kashyap V, Gudas LJ, Brenet F, Funk P, Viale A & Scandura JM 2011 Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid. J Biol Chem 286 3250-3260.

Korf B & Mikhail F 2007 Overview of genetic diagnosis in cancer. Curr Protoc Hum Genet 55 10.1.1-10.1.8

Laurence J 2012 Translating ideas into action: two new features initiated by Translational Research, as genomics enters the clinics. Transl Res 159 1-3.

Ross SA, Dwyer J, Umar A, Kagan J, Verma M, Van Bemmel DM & Dunn BK 2008 Introduction: diet, epigenetic events and cancer prevention. Nutr Rev 66 S1-S6.

Wadman M 2012 Child-study turmoil leaves bitter taste. Nature 485 287-288.

Wittwer J, Rubio-Aliaga I, Hoeft B, Bendik I, Weber P & Daniel H 2011 Nutrigenomics in human intervention studies: current status, lessons learned and future perspectives. Mol Nutr Food Res 55 341-358.

Woolf SH 2008 The meaning of translational research and why it matters. JAMA 299 3


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